Crystallinity of Dynasan (R) 114 and Dynasan (R) 118 matrices for the production of stable Miglyol (R)-loaded nanoparticles

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Severino, P (Author) Other; Pinho, SC (Author) Other; Souto, EB (Author) Other; Santana, MHA (Author) Other

Journal

Title: Journal of Thermal Analysis and Calorimetry

Vol. 108 No. 2

Pages: 101-108

ISSN: 1388-6150

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 20 Citations

Other information

Authenticus ID: P-002-BJ5

DOI: 10.1007/s10973-011-1613-7

Abstract (EN): This study focuses on the physicochemical characterization of lipid materials useful for the production of the so-called solid lipid nanoparticles (SLN) and nano-structured lipid carriers (NLC). The chosen lipids were Dynasan (R) 114 (glyceril trimyristate) and Dynasan (R) 118 (glyceril tristearate) as solid lipids (SL), melting temperature above 80 degrees C, and Miglyol (R) 812 (caprylic/capric triglyceride) and Miglyol (R) 840 (propylene glycol dicaprylate/dicaprate) as liquid lipids (LL), crystallizing below -15 degrees C. Raw lipids (pure or SL: LL mixtures) were analyzed by differential scanning calorimetry (DSC), wide angle X-ray diffraction (WAXD), and Polarized Light Microscopy (PLM), before and after tempering at 80 degrees C for 1 h. The selected SL:LL combination was 70% (Dynasan (R) 114 and 118) and 30% (Miglyol (R) 812 and 840) for the production of SLN and NLC by high-pressure homogenization (HPH), respectively. Particles with a mean size of 200 nm (poly-dispersity index <0.329) and zeta potential of -15 mV were obtained, and their long-term stability was confirmed for 3 months of storage at 7 degrees C.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8