Solid lipid nanoparticles: Classical methods of lab production [Nanopartículas de lipídios sólidos: Métodos clássicos de produção laboratorial]

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Souto, EB (Author) Other; Severino, P (Author) Other; Santana, MHA (Author) Other; Pinho, SC (Author) Other

Journal

Title: Quimica Nova

Vol. 34 No. 3

Pages: 1762-1769

ISSN: 0100-4042

Publisher: Sociedade Brasileira de Quimica

Indexing

Scopus - 26 Citations

Other information

Authenticus ID: P-008-1QQ

Abstract (EN): Solid lipid nanoparticles have been extensively investigated as drug delivery systems. These colloidal systems have major advantages compared to others more traditional. Reported advantages include sustained release, ability to solubilize lipophilic drugs, increased physical and chemical stability of labile molecules, decreased unwanted side-effects showing lower toxicity, and scale up facilities. This paper aims at reviewing the traditional methods of solid lipid nanoparticles production, such as fusion-emulsification (hot and cold), solvent evaporation-emulsification and microemulsion, dealing with the main technological parameters that influence the quality properties of solid lipid nanoparticles.

Language: Portuguese

Type (Professor's evaluation): Scientific