Biodegradable synthetic polymers: Raw-materials and production methods of microparticles for drug delivery and controlled release [Polímeros Sintéticos biodegradáveis: Matérias-primas e métodos de produção de micropartículas para uso em drug delivery e liberação controlada]

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Severino, P (Author) Other; Santana, MHA (Author) Other; Pinho, SC (Author) Other; Souto, EB (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Polimeros

Vol. 21

Pages: 286-292

ISSN: 0104-1428

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-008-201

DOI: 10.1590/s0104-14282011005000060

Abstract (EN): Microparticles produced from synthetic polymers have been widely used in the pharmaceutical field for encapsulation of drugs. These microparticles show several advantages such as drug protection, mucoadhesion, gastro-resistance, improved bioavailability and increased patient's compliance. In addition, it is possible to use lower amount of drug to achieve therapeutic efficiency with reduced local/ systemic adverse side effects and low toxicity. Synthetic polymers used for the production of microparticles are classified as biodegradable or non-biodegradable, being the former more popular since these do not need to be removed after drug release. Production of polymeric microparticles can be used for encapsulation of hydrophilic and hydrophobic drugs, by emulsification following solvent extraction/ evaporation, coacervation, methods that are revised in this paper, including advantages, disadvantages and viability of each methodology. Selection of methodology and synthetic polymer depends of the therapeutic purpose, as well as simplicity, reproducibility and possibility to scale up.

Language: Portuguese

Type (Professor's evaluation): Scientific

No. of pages: 7