Development, production and characterization of nanocrystals of poorly soluble drugs [Desenvolvimento, produção e caracterização de nanocristais de fármacos pouco solúveis]

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Fangueiro, JF (Author) Other; Marques, IR (Author) Other; Severino, P (Author) Other; Santana, MHA (Author) Other; Souto, EB (Author) Other

Journal

Title: Quimica Nova

Vol. 35 No. 9

Pages: 1848-1853

ISSN: 0100-4042

Publisher: Sociedade Brasileira de Quimica

Indexing

Scopus - 2 Citations

Other information

Authenticus ID: P-008-6ZB

DOI: 10.1590/s0100-40422012000900025

Abstract (EN): Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.

Language: Portuguese

Type (Professor's evaluation): Scientific