Retinoic acid (all-trans) presents antioxidant properties within human ovary and reduces progesterone production by human granulosa cells

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Fonseca, BM (Author) Other; Cruz, R (Author) Other; Pinto, B (Author) Other; Costa, L (Author) Other; Felgueira, E (Author) Other; oliveira, p (Author) ICBAS; Susana Casal (Author) FFUP; Rebelo, I (Author) FFUP

Journal

Title: Systems biology in reproductive medicine

Pages: 1-13

ISSN: 1939-6368

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-00X-FZR

DOI: 10.1080/19396368.2022.2120439

Abstract (EN): Both vitamin A and E support female reproduction and embryonic development. These vitamins have been associated with decreased fertility or failure to end the pregnancy in animals. An observational study was conducted on follicular fluid (FF) samples to determine the concentrations of fat-soluble vitamins of women undergoing in vitro fertilization and its correlation with assisted reproductive technology characteristics and pregnancy outcomes. Moreover, the effects of all-trans-retinoic acid (atRA) and alpha-tocopherol on granulosa cell viability, apoptosis, autophagy and hormonal production were evaluated. No association was identified between fat-soluble vitamin concentrations in FF and infertility aetiology, body mass index or woman's age. There were differences in follicular antioxidant profiles and ovarian response stimulation. In vitro evaluation of atRA and alpha-tocopherol reveals that, at physiological concentrations, both compounds may affect the viability of granulosa cells. In addition, these compounds are able to protect granulosa cells from oxidative stress, as well as to affect estradiol and progesterone production. Our data suggest that atRA and alpha-tocopherol levels should be well controlled as they may have implications in the function and viability of granulosa cells and highlights retinol as a marker of the oxidative defenses within ovary environment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13