Optimization of the mobile phase composition for preparative chiral separation of flurbiprofen enantiomers

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Ribeiro, AE (Author) Other; Graca, NS (Author) Other; Pais, LS (Author) Other; Alírio Rodrigues (Author) FEUP

Journal

Title: Separation and Purification Technology

Vol. 68 No. 1

Pages: 9-23

ISSN: 1383-5866

Publisher: Elsevier

Indexing

ISI Proceedings

ISI Web of Knowledge - 11 Citations

ISI Web of Science

Scopus - 7 Citations

COMPENDEX

Scientific classification

FOS: Engineering and technology > Chemical engineering

CORDIS: Technological sciences > Engineering > Chemical engineering

Other information

Authenticus ID: P-003-J46

DOI: 10.1016/j.seppur.2009.03.049

Abstract (EN): This work presents the experimental and simulation results obtained for the optimization of the mobile phase composition for the preparative separation of flurbiprofen enantiomers by liquid chromatography using an amylose-based chiral stationary phase (Chiralpak AD). The experimental work carried out includes solubility and adsorption isotherm measurements and pulse and breakthrough experiments under preparative conditions. The simulation work predicts the operation of a simulated moving bed (SMB) system for the separation of flurbiprofen enantiomers to compare the productivity and solvent consumption performances, for the different mobile phase compositions and using the experimental data obtained. This paper presents a new and different case study (flurbiprofen) of the one recently reported by the authors (ketoprofen enantiomers [A. Ribeiro, N. Graca, L. Pais, A. Rodrigues, Preparative separation of ketoprofen enantiomers: choice of mobile phase composition and measurement of competitive adsorption isotherms, Sep. Purif. Technol. 61 (2008) 375-383]), to clearly show that the optimization of the mobile phase composition for preparative chiral separation requires an individualized study, since different results are obtained even for enantiomers systems of the same family.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15