Two Surface Activation Strategies to Functionalize Cotton Fibers with Cys-LC-LL-37 Antibacterial Peptide

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Mouro, C (Author) Other; Pedrosa, M (Author) FEUP; Vaz, J (Author) Other; Gouveia, I (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: AATCC JOURNAL OF RESEARCH

Vol. 1

Pages: 27-33

ISSN: 2330-5517

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00K-TF9

DOI: 10.14504/ajr.1.6.4

Abstract (EN): This investigation aimed to determine which of two surface activation methods, N,N'-carbonyldiimidazole (CDI) or 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), allowed more effective bonding of Cys-LC-LL-37, an antimicrobial peptide (AMP), onto cotton fibers and which one presented greater antimicrobial activity. The antibacterial effect of the TEMPO-activated cotton functionalized with Cys-LC-LL-37 was more effective against Staphylococcus aureus, while the CDI-activated cotton covalently bonded to Cys-LC-LL-37 was more effective against Klebsiella pneumoniae. CDI-activated cotton retained a higher percentage of the AMP, making this bioactive strategy the choice for development of AMP antimicrobial textiles.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7