Small for gestational age very preterm infants present a higher risk of developing bronchopulmonary dysplasia

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Rocha, G (Author) Other; Filipa Flor-de-Lima (Author) FMUP; Paula MacHado, A (Author) Other; Guimarães, H (Author) Other; Proença, E (Author) Other; Carvalho, C (Author) Other; Martins, LG (Author) Other; Martins, T (Author) Other; Freitas, A (Author) Other; Dias, CP (Author) Other; Silva, A (Author) Other; Barroso, A (Author) Other; Diogo, I (Author) Other; Cassiano, G (Author) Other; Ramos, H (Author) Other; Abrantes, MM (Author) Other; Costa, P (Author) Other; Salazar, A (Author) Other; Vieira, F (Author) Other; Fontes, D (Author) Other; Barroso, R (Author) Other; Marques, T (Author) Other; Santos, V (Author) Other; Scortenschi, E (Author) Other; Santos, C (Author) Other; Vilela, F (Author) Other; Quintas, C (Author) Other

Journal

Title: Journal of Neonatal-Perinatal Medicine

Vol. 12

Pages: 419-427

ISSN: 1934-5798

Publisher: IOS PRESS

Indexing

Scopus - 7 Citations

Other information

Authenticus ID: P-00T-V0J

DOI: 10.3233/npm-180129

Abstract (EN): INTRODUCTION: Several studies assessed the influence of a low birth weight on bronchopulmonary dysplasia (BPD), but not all could find a significant association. Our aim was to assess the association between low birth weight and BPD in preterm infants, prospectively recruited at 11 level III Portuguese neonatal centers. METHODS: Obstetrical and neonatal data on mothers and preterm infants with gestational ages between 24 and 30 weeks, born during 2015 and 2016 after a surveilled pregnancy, were analyzed. Neonates were considered small for gestational age (SGA) when their birthweight was below the 10th centile of Fenton's growth chats and BPD was defined as the dependency for oxygen therapy until 36 weeks of corrected age. Statistical analysis was performed using IBM SPSS® statistics 23 and a p-value <0.05 was considered statistically significant. RESULTS: Out of 614, a total of 494 preterm infants delivered from 410 women were enrolled in the study; 40 (8.0%) infants with SGA criteria. SGA were more often associated with a single pregnancy, had greater use of antenatal corticosteroids, increased prevalence of gestational hypertensive disorders, C-section, rupture of membranes below 18 hours, rate of intubation in the delivery room, use of surfactant treatment, oxygen therapy, mechanical ventilation need, BPD, cystic periventricular leukomalacia, nosocomial sepsis and pneumonia; had lower prevalence of chorioamnionitis, and lower Apgar scores. The multivariate analysis by logistic regression, adjusted for BPD risk factors revealed a significant association between SGA and BPD: OR = 5.2 [CI: 1.46-18.58]; p = 0.01. CONCLUSION: The results of this study increase the scientific evidence that SGA is an independent risk factor for BPD.

Language: English

Type (Professor's evaluation): Scientific