Recent advances on dietary polyphenol's potential roles in Celiac Disease

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Dias, R (Author) Other; Pereira, CB (Author) Other; Perez Gregorio, R (Author) FCUP; Nuno Mateus (Author) FCUP; Victor de Freitas (Author) FCUP

Journal

Title: Trends in Food Science and Technology

Vol. 107

Pages: 213-225

ISSN: 0924-2244

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 35 Citations

Scopus - 38 Citations

Other information

Authenticus ID: P-00T-1SC

DOI: 10.1016/j.tifs.2020.10.033

Abstract (EN): Over the last years, epidemiological and population-based studies have suggested that a continuous and prolonged intake of fruits, vegetables and whole-grains - all rich sources of polyphenols -, may contribute to the prevention of age-related chronic diseases. However, conclusive proof and understanding of the health benefits provided by polyphenols on a Celiac Disease framework remain largely unexplored, notwithstanding the unmet need for alternative treatments to a gluten-free diet. Herein, this topic has been thoroughly explored based on the most recent scientific breakthroughs, bringing light into the remarkable potential and molecular mechanisms by which polyphenols may become valuable allies against the cytotoxicity of gluten proteins, based on their ability to interact with and reduce the bioavailability of immunogenic peptides, to counteract oxidative stress and inflammation, to regulate intestinal epithelial barrier integrity and function, to affect the gut microbial ecosystem, and to modulate immune responses. Altogether, this review opens up new horizons concerning the rational development, applicability and/or valorization of polyphenol-rich functional foods by industry as a promising nutritional strategy to manage and prevent Celiac Disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13