Molecular cloning and characterization of two novel transport proteins from rat kidney

• Type: Article in International Scientific Journal
• Date: 1998

Authors

Schomig, E (Author) Other; Spitzenberger, F (Author) Other; Engelhardt, M (Author) Other; Martel, F (Author) FMUP; Ording, N (Author) Other; Grundemann, D (Author) Other

Journal

Title: FEBS Letters

Vol. 425

Pages: 79-86

ISSN: 0014-5793

Publisher: Wiley-Blackwell

Indexing

Scopus - 85 Citations

Other information

Authenticus ID: P-007-8B8

DOI: 10.1016/s0014-5793(98)00203-8

Abstract (EN): The recent cloning of renal transport systems for organic anions and cations (OAT1, OCT1, and OCT2) opened the possibility to search, via polymerase chain reaction (PCR) homology screening, for novel transport proteins. Two integral membrane proteins, UST1 and UST2, were cloned from rat kidney. RT-PCR revealed that UST1 is confined to the kidney whereas UST2 mRNA was detected in all tested tissues. Sequence analyses suggest that UST1 and UST2, together with four related transporters, comprise, within the major facilitator superfamily, a so far unrecognized transporter family, termed amphiphilic solute facilitator (ASF) family. Characteristic signatures for the ASF family were identified.

Language: English

Type (Professor's evaluation): Scientific