Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype

• Type: Another Publication in an International Scientific Journal
• Date: 2011

Authors

Peixeiro, I (Author) Other; Silva, AL (Author) Other; Romao, L (Author) Other

Journal

Title: HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

Vol. 96

Pages: 905-913

ISSN: 0390-6078

Publisher: FERRATA STORTI FOUNDATION

Indexing

ISI Web of Knowledge - 25 Citations

Scopus - 15 Citations

Other information

Authenticus ID: P-002-R4J

DOI: 10.3324/haematol.2010.039206

Abstract (EN): Messenger RNA (mRNA) stability is a critical determinant that affects gene expression. Many pathways have evolved to modulate mRNA stability in response to developmental, physiological and/or environmental stimuli. Eukaryotic mRNAs have a considerable range of half-lives, from as short as a few minutes to as long as several days. Human globin mRNAs constitute an example of highly stable mRNAs. However, a wide variety of naturally occurring mutations that result in the clinical syndrome of thalassemia can trigger accelerated mRNA decay thus controlling mRNA quality prior to translation. Distinct surveillance mechanisms have been described as being targeted for specific defective globin mRNAs. Here, we review mRNA stability mechanisms implicated in the control of beta-globin gene expression and the surveillance pathways that prevent translation of aberrant beta-globin mRNAs. In addition, we emphasize the importance of these pathways in modulating the severity of the beta-thalassemia phenotype.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9