The mammalian nonsense-mediated mRNA decay pathway: To decay or not to decay! Which players make the decision?

• Type: Another Publication in an International Scientific Journal
• Date: 2009

Authors

Silva, AL (Author) Other; Romao, L (Author) Other

Journal

Title: FEBS Letters

Vol. 583

Pages: 499-505

ISSN: 0014-5793

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 94 Citations

Scopus - 82 Citations

Other information

Authenticus ID: P-003-N7Y

DOI: 10.1016/j.febslet.2008.12.058

Abstract (EN): Nonsense-mediated mRNA decay (NMD) degrades mRNAs carrying premature translation termination codons (PTCs). Although the core process and several NMD effectors are conserved among species, the involvement of a splicing-dependent signal seems to be specific for mammalian PTC definition. Still, recent data shed new light on physical parameters and mechanistic pathways involved in NMD. Here, we examine these findings, updating the roles for potential NMD players, such as the exon junction complex and the cytoplasmic poly(A)-binding protein 1 - the former acting as enhancer rather than an essential factor and the latter functioning as NMD repressor.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7