New chiral stationary phases for liquid chromatography based on small molecules: Development, enantioresolution evaluation and chiral recognition mechanisms

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Phyo, YZ (Author) Other; Teixeira, J (Author) Other; Tiritan M.E. (Author) FFUP; Cravo, S (Author) Other; Palmeira, A (Author) FFUP; Luis Gales (Author) ICBAS; Silva, AMS (Author) Other; Pinto, MMM (Author) Other; Kijjoa, A (Author) Other; Carla Fernandes (Author) FFUP

Journal

Title: Chirality

Vol. 32

Pages: 81-97

ISSN: 0899-0042

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-00R-DDK

DOI: 10.1002/chir.23142

Abstract (EN): Recently, we reported the development of new chiral stationary phases (CSPs) for liquid chromatography (LC) based on chiral derivatives of xanthones (CDXs). Based on the most promising CDX selectors, 12 new CSPs were successfully prepared starting from suitable functionalized small molecules including xanthone and benzophenone derivatives. The chiral selectors comprising one, two, three, or four chiral moieties were covalently bonded to a chromatographic support and further packed into LC stainless-steel columns (150 x 2.1 mm I.D.). The enantioselective performance of the new CSPs was evaluated by LC using different classes of chiral compounds. Specificity for enantioseparation of some CDXs was observed in the evaluation of the new CSPs. Besides, assessment of chiral recognition mechanisms was performed by computational studies using molecular docking approach, which are in accordance with the chromatographic parameters. X-Ray analysis was used to establish a chiral selector 3D structure.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17