Structures, Activities and Drug-Likeness of Anti-Infective Xanthone Derivatives Isolated from the Marine Environment: A Review

• Type: Another Publication in an International Scientific Journal
• Date: 2019

Authors

Loureiro, DRP (Author) Other; Jose X Soares (Author) FFUP; Costa, JC (Author) Other; Magalhaes, AF (Author) Other; Azevedo, CMG (Author) Other; Pinto, MMM (Author) Other; Carlos Afonso (Author) FFUP

Journal

Title: Molecules

Vol. 24

Final page: 243

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 18 Citations

Other information

Authenticus ID: P-00Q-2GC

DOI: 10.3390/molecules24020243

Abstract (EN): Marine organisms represent almost half of total biodiversity and are a very important source of new bioactive substances. Within the varied biological activities found in marine products, their antimicrobial activity is one of the most relevant. Infectious diseases are responsible for high levels of morbidity and mortality and many antimicrobials lose their effectiveness with time due to the development of resistance. These facts justify the high importance of finding new, effective and safe anti-infective agents. Among the variety of biological activities of marine xanthone derivatives, one that must be highlighted is their anti-infective properties. In this work, a literature review of marine xanthones with anti-infective activity, namely antibacterial, antifungal, antiparasitic and antiviral, is presented. Their structures, biological activity, sources and the methods used for bioactivity evaluation are described. The xanthone derivatives are grouped in three sets: xanthones, hydroxanthones and glycosylated derivatives. Moreover, molecular descriptors, biophysico-chemical properties, and pharmacokinetic parameters were calculated, and the chemical space occupied by marine xanthone derivatives is recognized. The chemical space was compared with marketed drugs and framed accordingly to the drug-likeness concept in order to profile the pharmacokinetic of anti-infective marine xanthone derivatives.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 23