Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Facioni, MS (Author) Other; Soares, J (Author) Other; Adinolfi, B (Author) Other; Gomes, S (Author) Other; Raimundo, L (Author) Other; Contini, A (Author) Other; Ruffoni, B (Author) Other; Azzarà, A (Author) Other; Tavanti, A (Author) Other; Bertoli, A (Author) Other; Pistelli, L (Author) Other; Lucilia Saraiva (Author) FFUP; Scarpato, R (Author) Other

Journal

Title: Natural product communications

Vol. 13

Pages: 1105-1110

ISSN: 1934-578X

Publisher: SAGE

Indexing

Scopus - 1 Citation

Other information

Authenticus ID: P-00P-MA7

Abstract (EN): Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.

Language: English

Type (Professor's evaluation): Scientific