Frequency of self-reported drug allergy A systematic review and meta-analysis with meta-regression

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Sousa Pinto, B (Author) FMUP; Fonseca, J (Author) FMUP; Gomes, ER (Author) Other

Journal

Title: Annals of Allergy, Asthma and Immunology

Vol. 119

Pages: 362-+

ISSN: 1081-1206

Publisher: American College of Allergy, Asthma, & Immunology

Indexing

ISI Web of Knowledge - 92 Citations

Scopus - 94 Citations

Other information

Authenticus ID: P-00N-2PC

DOI: 10.1016/j.anai.2017.07.009

Abstract (EN): Background: Patients reporting drug allergy are treated with second-line therapies, with possible negative clinical and health consequences. Objective: To assess the prevalence of self-reported drug allergy. Methods: We performed a systematic review of observational studies assessing the prevalence of self-reported drug allergy. We searched 4 electronic databases. From selected studies, we extracted data on self-reported drug allergy prevalence, study design, participants' demographic characteristics, reported clinical manifestations, and suspected culprit drugs. We performed a random-effects meta-analysis followed by a meta-regression. Results: Fifty-three studies were included in the systematic review, assessing a total of 126,306 participants, of whom 8.3% (range across studies 0.7-38.5%) self-reported drug allergy. Cutaneous manifestations were reported by 68.2% of participants, and anaphylactic or systemic reactions were reported by 10.8%. Antibiotics, nonsteroidal anti-inflammatory drugs, and anesthetics were the most frequently reported culprit drug classes. The frequency of self-reported drug allergy was higher in female (11.4%) than in male (7.2%) patients, adults (10.0%) than in children (5.1%), and in studies in the medical setting (15.9% in inpatients, 11.4% in outpatients) than in the general population (5.9%). The meta-analysis rendered a pooled prevalence of 7.9% (95% confidence interval 6.4-9.6), and the meta-regression identified study region, participants' age group, and study setting as factors associated with significant heterogeneity. Confirmation tests (including skin, in vitro, and drug provocation tests) were performed in only 3 studies. Conclusion: The prevalence of self-reported drug allergy is highly variable and is higher in female patients, adults, and inpatients. To overcome this variability, further studies using confirmation tests are needed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14