Resumo (PT):
Abstract (EN):
Dental caries remains the most prevalent and costly oral infectious
disease worldwide, encouraging the search for new and more effective antimicrobials.
Therefore, the aim of this work was to study the antimicrobial action of selected phytochemicals (eugenol, citronellol, sabinene hydrate, trans-cinnamaldehyde, terpineol and
cinnamic acid) against Streptococcus mutans in planktonic and biofilm states as well as
the cytotoxicity of these compounds.
Methods. The antibacterial activity of the selected compounds was evaluated by the
determination of the minimal bactericidal concentration. The resazurin assay was used
to assess the metabolic activity of sessile S. mutans. The cytotoxicity was determined
using a fibroblast cell line.
Results. Among the tested phytochemicals, citronellol, cinnamic acid and transcinnamaldehyde were the most effective against both planktonic and sessile S. mutans,
an effect apparently related to their hydrophobic character. Additionally, these three
compounds did not compromise fibroblasts cell viability.
Discussion. Citronellol, cinnamic acid and trans-cinnamaldehyde demonstrated significant antimicrobial activity and low cytotoxicity proposing their potential as a novel
group of therapeutic compounds to control oral infectious diseases. Moreover, their
effects are particularly relevant when benchmarked against eugenol, a phytochemical
commonly used for prosthodontic applications in dentistry.
Language:
English
Type (Professor's evaluation):
Scientific
No. of pages:
17