Synthesis and characterization of Locust Bean Gum derivatives and their application in the production of nanoparticles

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Braz, L (Author) Other; Grenha, A (Author) Other; Corvo, MC (Author) Other; Lourenco, JP (Author) Other; Ferreira, DC (Author) FFUP; Sarmento, B (Author) Other; Rosa da Costa, AMR (Author) Other

Journal

Title: Carbohydrate Polymers

Vol. 181

Pages: 974-985

ISSN: 0144-8617

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-00N-CVF

DOI: 10.1016/j.carbpol.2017.11.052

Abstract (EN): The development of LBG-based nanoparticles intending an application in oral immunization is presented. Nanoparticle production occurred by mild polyelectrolyte complexation, requiring the chemical modification of LBG. Three LBG derivatives were synthesized, namely a positively charged ammonium derivative (LBGA) and negatively charged sulfate (LBGS) and carboxylate (LBGC) derivatives. These were characterized by Fourier-transform infrared spectroscopy, elemental analysis, nuclear magnetic resonance spectroscopy, gel permeation chromatography, and x-ray diffraction. As a pharmaceutical application was aimed, a toxicological analysis of the derivatives was performed by both MTT test and LDH release assay. Several nanoparticle formulations were produced using LBGA or chitosan (CS) as positively charged polymers, and LBGC or LBGS as negatively charged counterparts, producing nanoparticles with adequate properties regarding an application in oral immunization.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12