Multifunctional PLLA-ceramic fiber membranes applications for bone regeneration

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Santos, JD (Author) FEUP; Silva, D.M. (Author) Other; Gomes PS (Author) FMDUP; Fernandes MH (Author) FMDUP; Santos, J.D. (Author) Other; Sencadas, V. (Author) Other

Journal

Title: Journal of Colloid and Interface Science

Vol. 504

Pages: 101-110

ISSN: 0021-9797

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

ISI Web of Science

Scopus - 18 Citations

Scientific classification

CORDIS: Health sciences

FOS: Medical and Health sciences

Other information

Authenticus ID: P-00M-TJ8

DOI: 10.1016/j.jcis.2017.05.032

Abstract (EN): A novel method to process electrospun poly(L-lactic acid) (PLLA) membranes incorporating glass reinforced hydroxyapatite granules (gHA) interspacially between the polymeric fibers is reported, thus increasing the surface area for cellular interactions. gHA granules (<= 150 mu m) electrospun together with the polymer solution, lead to an average fiber diameter of 550 150 nm for pristine PLLA and 440 170 nm for the composite samples. An increase of the overall porosity was observed, from 79 +/- 3% for the PLLA up to 88 +/- 5% for the hybrid samples, keeping material's wettability and mechanical properties. Bone-bonding ability showed that both samples induced HA crystal nucleation, but with a distinct pattern of mineral deposition. gHA microcomposite allows a better F-actin cytoskeleton organization during the initial adhesion and spreading, favoring cell-fibers and cell-to-cell interactions and enhanced alkaline phosphatase activity, making them potential candidates for bone healing strategies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10