Primaquine-based ionic liquids as a novel class of antimalarial hits

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Ferraz, R (Author) Other; Noronha, J (Author) Other; Murtinheira, F (Author) Other; Nogueira, F (Author) Other; Machado, M (Author) Other; Prudencio, M (Author) Other; Parapini, S (Author) Other; D'Alessandro, S (Author) Other; Catia Teixeira (Author) FCUP; Gomes, A (Author) Other; Prudencio, C (Author) Other; Paula Gomes (Author) FCUP

Journal

Title: RSC Advances

Vol. 6

Pages: 56134-56138

ISSN: 2046-2069

Publisher: Royal Society of Chemistry

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 26 Citations

Other information

Authenticus ID: P-00K-JVJ

DOI: 10.1039/c6ra10759a

Abstract (EN): Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial drugs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5