Transthyretin regulates hippocampal 14-3-3 zeta protein levels

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Vieira, M (Author) Other; Maria Joao Saraiva (Author) ICBAS

Journal

Title: FEBS Letters

Vol. 587

Pages: 1482-1488

ISSN: 0014-5793

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-005-0P9

DOI: 10.1016/j.febslet.2013.03.011

Abstract (EN): Transthyretin is the carrier protein of thyroxine and retinol in plasma and cerebrospinal fluid and has been described also as a neuroprotective molecule. 14-3-3 Proteins are very important in many cellular processes, being their absence related with deficits in memory and learning. The analysis of the relationship between these two proteins is the main objective of this work. We found that hippocampi of young TTR null mice presented lower levels of 14-3-3 zeta protein, but no changes in gene expression when compared to TTR wild type littermates were noted. Cellular studies ascribed this finding to increased degradation of 14-3-3 zeta in lysosomes in the absence of TTR, increasing autophagy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7