Pharmacokinetics of blackberry anthocyanins consumed with or without ethanol: A randomized and crossover trial

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Marques, Claúdia (Author) Other; Iva Fernandes (Author) FCUP; Norberto, Sónia (Author) FMUP; Sá-Couto CD (Author) FMUP; Teixeira, Diana (Author) Other; Freitas, Victor de (Author) Other; Nuno Mateus (Author) FCUP; Conceicao Calhau (Author) FMUP; Faria, Ana (Author) FCNAUP

Journal

Title: Molecular Nutrition and Food Research

Vol. 60 No. 11

Pages: 2319-2330

ISSN: 1613-4125

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 32 Citations

Scopus - 36 Citations

Pubmed / Medline

Scientific classification

CORDIS: Health sciences

FOS: Medical and Health sciences

Other information

Authenticus ID: P-00M-8V0

DOI: 10.1002/mnfr.201600143

Abstract (EN): Scope: This study was designed to evaluate the influence of ethanol on the bioavailability of blackberry anthocyanins. Methods and results: A total of 18 participants were recruited to consume 250 mL of a blackberry puree (650 mg of anthocyanins) without (BBP) or with 12% ethanol (BBP 12%). Venous blood was collected from participants at baseline and at 15, 30, 60, and 120 min after puree ingestion. Urine samples were collected at baseline and at 120 min. Plasma and urine concentration of anthocyanins and anthocyanin conjugates were quantified by HPLC-DAD. Methylcyanidin- glucuronide (Me-Cy-Glucr) and 3-methyl-cyanidin-3-glucoside (3-Me-Cy3glc) were the main anthocyanin conjugates detected in all plasma and urine samples. Urinary concentration of these anthocyanin conjugates were positively correlatedwith their plasma concentration. Ethanol increased plasma Cmax of Me-Cy-Glucr and 3-Me-Cy3glc. Participants were then stratified according to their body mass index (BMI) and body fat mass. After BBP consumption, plasma Cmax of Me-Cy-Glucr and 3-Me-Cy3glc tended to be decreased in overweight/obese participants, in comparison to normal weight participants. The increase on plasma Cmax of Me-Cy-Glucr and 3-Me-Cy3glc induced by ethanol was more pronounced in the group of overweight/obese participants. Conclusions: Ethanol seems to enhance Cy3glc metabolism that appears to be compromised in overweight and obese individuals.

Language: English

Type (Professor's evaluation): Scientific

Notes: <a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&KeyUT=000389134200001">Indexado na ISI Web of Science</a> <a href="https://www.ncbi.nlm.nih.gov/pubmed/27306520">Indexado na Pubmed</a> <a href="http://www.scopus.com/record/display.url?eid=2-s2.0-84981541467&origin=inward">Indexado na Scopus</a>

No. of pages: 12