Fabrication of highly porous scaffold materials based on functionalizedoligolactides and preliminary results on their use in bone tissue engineering

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Vogt, S (Author) Other; Larcher, Y (Author) Other; Beer, B (Author) Other; Wilke, I (Author) Other; Schnabelrauch, M (Author) Other; Winet, H (Author) Other; Mário Adolfo Barbosa (Author) FEUP

Journal

Title: European Cells and Materials

Vol. 4

Pages: 30-38

ISSN: 1473-2262

Publisher: AO Research Institute Davos

Indexing

Scopus - 30 Citations

Other information

Authenticus ID: P-008-P6C

Abstract (EN): Tissue engineering offers a promising new approach to repair bone defects. Its practical realisation is connected with the development of suitable scaffold materials. In the present work, functionalized oligolactides have been prepared and used as macromers for the scaffold fabrication. The developed fabrication process leads to highly porous scaffolds, available in various shapes and sizes, with an open interconnective pore structure and porosities up to 90%. Degradable or even osteoconductive components as well as biocompatible comonomers can be used as additives to modulate the scaffold properties. Under in vitro conditions, the scaffolds exhibit a continuous degradation with varying degradation rates depending on their material composition. In vitro studies on the cultivation of osteoblasts on the scaffolds were performed and revealed their excellent biocompatibility. Cell growth on the scaffold surfaces and inside the scaffolds, formation of extracellular matrix and starting mineralization were detected by microscopical and histological analyses. Based on these results the developed materials are well-suited candidates for the design of tailor-made matrices in bone tissue engineering.

Language: English

Type (Professor's evaluation): Scientific