Trefoil factors: from ulceration to neoplasia

• Type: Another Publication in an International Scientific Journal
• Date: 2005

Authors

Regalo, G (Author) Other; Wright, NA (Author) Other; Machado JC (Author) FMUP

Journal

Title: Cellular and Molecular Life Sciences

Vol. 62

Pages: 2910-2915

ISSN: 1420-682X

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 45 Citations

Scopus - 48 Citations

Other information

Authenticus ID: P-000-051

DOI: 10.1007/s00018-005-5478-4

Abstract (EN): There is convincing evidence that trefoil factors (TFFs) do play an important role in tumourigenesis. However, their specific roles in cancer are not yet clear. Recently, TFFs have been shown to interfere with crucial biological processes such as cell proliferation, differentiation, apoptosis and angiogenesis. Research on the function of TFFs and its relationship with specific signal transduction pathways has also advanced significantly. As a consequence, some ideas about the role of TFFs in cancer have started to take shape. The objective of this review is to summarize and discuss current knowledge on the relationship between TFFs and cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6