Pathogenesis of Helicobacter pylori Infection

• Type: Another Publication in an International Scientific Journal
• Date: 2009

Authors

Costa, AC (Author) Other; Figueiredo C (Author) FMUP; Touati, E (Author) Other

Journal

Title: Helicobacter

Vol. 14 No. 6

Pages: 15-20

ISSN: 1083-4389

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 66 Citations

Scopus - 68 Citations

Other information

Authenticus ID: P-003-G47

DOI: 10.1111/j.1523-5378.2009.00702.x

Abstract (EN): Helicobacter pylori induces chronic inflammation of the gastric mucosa, but only a proportion of infected individuals develop peptic ulcer disease or gastric carcinoma. Reasons underlying these observations include differences in bacterial pathogenicity as well as in host susceptibility. Numerous studies published in the last year provided new insight into H. pylori virulence factors, their interaction with the host and consequences in pathogenesis. These include the role of bacterial genetic diversity in host colonization and persistence, outer membrane proteins and modulation of adhesin expression, new aspects of VacA functions, and CagA and its phosphorylation-dependent and -independent cellular effects. This article will also review the recent novel findings on the interactions of H. pylori with diverse host epithelial signaling pathways and events involved in the initiation of carcinogenesis, including genetic instability and dysregulation of DNA repair.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6