E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Carneiro, P (Author) Other; Sofia Fernandes, MS (Author) Other; Figueiredo, J (Author) Other; Caldeira, J (Author) Other; Carvalho, J (Author) Other; Pinheiro, H (Author) Other; Marina Leite (Author) Other; Melo, S (Author) Other; Oliveira, P (Author) Other; Simoes Correia, J (Author) Other; Oliveira, MJ (Author) FCUP; Carneiro F (Author) FMUP; Figueiredo C (Author) FMUP; Joana Paredes (Author) FMUP; Oliveira, C (Author) Other; Seruca, R (Author) FMUP

Journal

Title: FEBS Letters

Vol. 586

Pages: 2981-2989

ISSN: 0014-5793

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 64 Citations

Scopus - 67 Citations

Other information

Authenticus ID: P-002-6T1

DOI: 10.1016/j.febslet.2012.07.045

Abstract (EN): E-cadherin plays a major role in cell-cell adhesion and inactivating germline mutations in its encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside from its recognized role in early tumourigenesis, E-cadherin is also pivotal for tumour progression, including invasion and metastization. Herein, we discuss E-cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9