Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Isabel C F R Ferreira (Author) Other; Sandrina A Heleno (Author) Other; Filipa S Reis (Author) Other; Dejan Stojkovic (Author) Other; Maria Joao R P Queiroz (Author) Other; Helena Vasconcelos, MH (Author) FFUP; Marina Sokovic (Author) Other

Journal

Title: Phytochemistry

Vol. 114

Pages: 38-55

ISSN: 0031-9422

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 113 Citations

Scopus - 160 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-00G-5AD

DOI: 10.1016/j.phytochem.2014.10.011

Abstract (EN): Ganoderma genus comprises one of the most commonly studied species worldwide, Ganoderma lucidum. However, other Ganoderma species have been also reported as important sources of bioactive compounds. Polysaccharides are important contributors to the medicinal properties reported for Ganoderma species, as demonstrated by the numerous publications, including reviews, on this matter. Yet, what are the chemical features of Ganoderma polysaccharides that have bioactivity? In the present manuscript, the chemical features of Ganoderma polysaccharides with reported antioxidant, antitumor and antimicrobial activities (the most studied worldwide) are analyzed in detail. The composition of sugars (homo- versus hetero-glucans and other polysaccharides), type of glycosidic linkages, branching patterns, and linkage to proteins are discussed. Methods for extraction, isolation and identification are evaluated and, finally, the bioactivity of polysaccharidic extracts and purified compounds are discussed. The integration of data allows deduction of structure-activity relationships and gives clues to the chemical aspects involved in Ganoderma bioactivity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18