Transthyretin Deposition in Familial Amyloidotic Polyneuropathy

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Saraiva, MJ (Author) ICBAS; Magalhaes, J (Author) Other; Ferreira, N (Author) Other; Almeida, MR (Author) ICBAS

Journal

Title: Current Medicinal Chemistry

Vol. 19

Pages: 2304-2311

ISSN: 0929-8673

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 42 Citations

Scopus - 43 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-ANX

DOI: 10.2174/092986712800269236

Abstract (EN): The subject of the review is on hereditary transthyretin (TTR) amyloidosis which is a genetically transmitted disease that results from a mutation in the gene encoding the plasma TTR protein. TTR is a transport protein for thyroid hormones and vitamin A and is predominantly synthesised in the liver. Although originally regarded as a rare disease, it is now becoming clear that many kindreds exist worldwide. Current knowledge and hypotheses on the biology of TTR, mechanisms of TTR amyloid fibril formation, phenotypic consequences TTR amyloid deposition and pre-clinical models of the disease will be discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8