Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Silva, S (Author) Other; Sepodes, B (Author) Other; Rocha, J (Author) Other; Direito, R (Author) Other; Fernandes, A (Author) Other; Brites, D (Author) Other; Freitas, M (Author) Other; Fernandes, E (Author) FFUP; Bronze, MR (Author) Other; Figueira, ME (Author) Other

Journal

Title: Journal of Nutritional Biochemistry

Vol. 26

Pages: 360-368

ISSN: 0955-2863

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 35 Citations

Scopus - 55 Citations

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Authenticus ID: P-00A-9CD

DOI: 10.1016/j.jnutbio.2014.11.011

Abstract (EN): Virgin olive oil is the primary source of fat in the Mediterranean diet, and its beneficial health effects have been related with oleic acid and phenolic compounds content. Hydroxytyrosol, a typical virgin olive oil phenolic compound, has beneficial antioxidant and anti-inflammatory properties as previously reported. The aim of this study was to evaluate the effect of hydroxytyrosol-supplemented refined olive oil at 0.5 and 5 mg/kg in a rodent model of rheumatoid arthritis. Rheumatoid arthritis was induced by intradermic administration, in male Wistar rats, of Freund's adjuvant with collagen type II on days 1 and 21. Hydroxytyrosol-supplemented refined olive oils were administrated by gavage from day 23 until day 35. The treatment at 5-mg/kg dose significantly decreased paw edema (P<.01), histological damage, cyclooxygenase-2 and inducible nitric oxide synthase expression, and markedly reduced the degree of bone resorption, soft tissue swelling and osteophyte formation, improving articular function in treated animals. Acute inflammation, induced by carrageenan, was also evaluated for hydroxytyrosol-supplemented refined olive oils at 0.5 and 5 mg/kg. Both doses significantly reduced paw edema (P<.001). Our results suggest that the supplementation of refined olive oil with hydroxytyrosol may be advantageous in rheumatoid arthritis with significant impact not only on chronic inflammation but also on acute inflammatory processes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9