The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A Systematic Review

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Soares, S (Author) Other; Susana Guerreiro (Author) FCNAUP; Cruz Martins, N (Author) Other; Faria, I (Author) Other; Baylina, P (Author) Other; Sales, MG (Author) Other; Correa Duarte, MA (Author) Other; Fernandes, R (Author) Other

Journal

Title: Frontiers in Oncology

Vol. 11

ISSN: 2234-943X

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 0 Citations

Scientific classification

CORDIS: Health sciences

FOS: Medical and Health sciences

Other information

Authenticus ID: P-00V-9QE

DOI: 10.3389/fonc.2021.704664

Abstract (EN): In the last years, extensive investigation on miRNomics have shown to have great advantages in cancer personalized medicine regarding diagnosis, treatment and even clinical outcomes. Prostate cancer (PCa) is the second most common male cancer and about 50% of all PCa patients received radiotherapy (RT), despite some of them develop radioresistance. Here, we aim to provide an overview on the mechanisms of miRNA biogenesis and to discuss the functional impact of miRNAs on PCa under radiation response. As main findings, 23 miRNAs were already identified as being involved in genetic regulation of PCa cell response to RT. The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. Identification of miRNAs panel can be thus considered an upcoming and potentially useful strategy in PCa diagnosis, given that radioresistance biomarkers, in both prognosis and therapy still remains a challenge.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14