The dopamine receptor D-5 gene shows signs of independent erosion in toothed and baleen whales

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Alves, LQ (Author) Other; Alves, J (Author) Other; Ribeiro, R (Author) Other; Ruivo, R (Author) Other; Filipe F C Castro (Author) FCUP

Journal

Title: PeerJ

Vol. 7

ISSN: 2167-8359

Publisher: PeerJ

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00R-5N8

DOI: 10.7717/peerj.7758

Abstract (EN): To compare gene loci considering a phylogenetic framework is a promising approach to uncover the genetic basis of human diseases. Imbalance of dopaminergic systems is suspected to underlie some emerging neurological disorders. The physiological functions of dopamine are transduced via G-protein-coupled receptors, including DRD5 which displays a relatively higher affinity toward dopamine. Importantly, DRD5 knockout mice are hypertense, a condition emerging from an increase in sympathetic tone. We investigated the evolution of DRD5, a high affinity receptor for dopamine, in mammals. Surprisingly, among 124 investigated mammalian genomes, we found that Cetacea lineages (Mysticeti and Odontoceti) have independently lost this gene, as well as the burrowing Chrysochloris asiatica (Cape golden mole). We suggest that DRD5 inactivation parallels hypoxia-induced adaptations, such as peripheral vasoconstriction required for deep-diving in Cetacea, in accordance with the convergent evolution of vasoconstrictor genes in hypoxia-exposed animals. Our findings indicate that Cetacea are natural knockouts for DRD5 and might offer valuable insights into the mechanisms of some forms of vasoconstriction responses and hypertension in humans.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15