The influence of various phenolic compounds on scavenging activity assessed by an enzymatic method

• Type: Article in International Scientific Journal
• Date: 1999

Authors

de Gaulejac, NSC (Author) Other; Vivas, N (Author) Other; Victor de Freitas (Author) FCUP; Bourgeois, G (Author) Other

Journal

Title: Journal of the Science of Food and Agriculture

Vol. 79

Pages: 1081-1090

ISSN: 0022-5142

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 57 Citations

Scopus - 85 Citations

Other information

Authenticus ID: P-001-47Z

DOI: 10.1002/(sici)1097-0010(199906)79:8<1081::aid-jsfa330>3.0.co;2-g

Abstract (EN): The effect of pure monomeric and dimeric procyanidins on superoxide anion radicals (O(2)degrees(-)) was studied with an enzymatic method and their IC50 was determined, A comparative study of the results suggested that the antiradical potential of these phenolic compounds closely depends on their stereochemical structure. Modification of the chiral carbon, C-3 involved in the oxidation mechanism induces differences in the scavenging action of (+)-catechin (2R:3S) or (-)-epicatechin (2R:3R), The stereochemical conformation of the interflavan linkage (axial or pseudo) according to the chemical nature of dimeric procyanidin units also influences the radical oxidation mechanism. The nature of the interflavan linkage between the two units in dimeric procyanidins (C-4-C-8 or C-4-C-6 linkage) is an important factor responsible for effectiveness of the behaviour polyphenols towards O2 degrees(-). The extraction of oligomeric procyanidins in grape seeds enabled us to study the effect of polymerisation and galloylation on their scavenging activities. The results clearly showed that the molecular scavenging mechanism of these molecules is closely connected with their spatial conformation. (C) 1999 Society of Chemical Industry.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10