Carbohydrate carbamate coated onto microporous silica: Application to chiral analysis of commercial pharmaceutical drugs

• Type: Article in International Conference Proceedings Book
• Date: 1996

Authors

Cass, QB (Author) Other; Bassi, AL (Author) Other; Calafatti, SA (Author) Other; Matlin, SA (Author) Other; Tiritan M.E. (Author) Other; Moreira De Campos, LM (Author) Other

Conference proceedings International

Title: Chirality

Pages: 143-146

Indexing

Scopus - 17 Citations

Other information

Authenticus ID: P-009-14V

DOI: 10.1002/(sici)1520-636x(1996)8:1<143::aid-chir21>3.0.co;2-m

Abstract (EN): The enantioselectivity of a series of chiral analytes was examined on tris-(3,5-dimethylphenyl carbamate) coated onto microporous APS-silica. The effects of the nature of the carbohydrate, the weight ratio of carbamate/support and the type of alcohol present in the mobile phase were investigated. Among the chiral analytes examined, propanolol showed an extremely good resolution. The resolution of tetramisole was optimized and the method developed was shown to be suitable for analysis of the drug in commercial tablets and in a suspension.

Language: English

Type (Professor's evaluation): Scientific