Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem"

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Nelson G.M. Gomes (Author) FFUP; Ramesh Dasari (Author) Other; Sunena Chandra (Author) Other; Robert Kiss (Author) Other; Alexander Kornienko (Author) Other

Journal

Title: Marine Drugs

Vol. 14

Pages: 98-98

ISSN: 1660-3397

Publisher: MDPI

Indexing

ISI Web of Knowledge - 27 Citations

Scopus - 52 Citations

Other information

Authenticus ID: P-00K-GQ3

DOI: 10.3390/md14050098

Abstract (EN): Marine invertebrates provide a rich source of metabolites with anticancer activities and several marine-derived agents have been approved for the treatment of cancer. However, the limited supply of promising anticancer metabolites from their natural sources is a major hurdle to their preclinical and clinical development. Thus, the lack of a sustainable large-scale supply has been an important challenge facing chemists and biologists involved in marine-based drug discovery. In the current review we describe the main strategies aimed to overcome the supply problem. These include: marine invertebrate aquaculture, invertebrate and symbiont cell culture, culture-independent strategies, total chemical synthesis, semi-synthesis, and a number of hybrid strategies. We provide examples illustrating the application of these strategies for the supply of marine invertebrate-derived anticancer agents. Finally, we encourage the scientific community to develop scalable methods to obtain selected metabolites, which in the authors' opinion should be pursued due to their most promising anticancer activities.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 39