Ovarian Leydig cell tumor in a post-menopausal patient with severe hyperandrogenism

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Souto, SB (Author) Other; Baptista, PV (Author) Other; Braga, DC (Author) Other; Carvalho, Davide (Author) FMUP

Journal

Title: Arquivos Brasileiros de Endocrinologia e Metabologia

Vol. 58

Pages: 68-70

ISSN: 0004-2730

Publisher: Universidade de São Paulo

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 20 Citations

Other information

Authenticus ID: P-009-J05

DOI: 10.1590/0004-2730000002461

Abstract (EN): Leydig cell tumors are rare ovarian steroid cell neoplasms. More than 75% of patients show signs of virilization due to overproduction of testosterone. We report a case of an 8-year-old woman with progressive signs of virilization, and presenting vaginal bleeding. Clinical analyses revealed high levels of serum testosterone, delta 4-androstenedione and estradiol, and also inappropriate low levels of gonadotrophins for a post-menopausal woman. Transvaginal ultrasound showed no evidence of ovarian tumor, but pelvic and abdominal computerized axial tomography imaging revealed a left ovarian solid nodule, and no evidence of alteration in the adrenal glands. Total hysterectomy and bilateral salpingoophorectomy were performed. Histopathology and immunohistochemistry confirmed the diagnosis of Leydig cell tumor. After surgery, androgen levels returned to normal, and there was regression of the signs of virilization.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3