Preparation and characterization of injectable chitosan-hydroxyapatite microspheres

• Type: Another Publication in an International Scientific Journal
• Date: 2004

Authors

Granja, PL (Author) Other; Silva, AIN (Author) Other; Borges, JP (Author) Other; Barrias, CC (Author) Other; Amaral, IF (Author) Other

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 11 Citations

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

Other information

Authenticus ID: P-000-CBG

Abstract (EN): The combination of chitosan and hydroxyapatite (HAp) in the form of injectable, porous and biodegradable structures seems to be an interesting route to promote localized bone regeneration, especially with the incorporation of cells or cell-targeted molecules. In the present work, chitosan-HAp microspheres were prepared and characterized in terms of size, morphology, water sorption and structure. Chitosan-HAp porous microspheres were successfully prepared using tripolyphosphate as coagulating agent. The size increased and the water sorption decreased with increasing HAp contents. The ceramic particles were well embedded and homogeneously distributed within the polymer matrix.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4