DO INVADING LEUKOCYTES CONTRIBUTE TO THE DECREASE IN GLUTATHIONE CONCENTRATIONS INDICATING OXIDATIVE STRESS IN EXERCISED MUSCLE, OR ARE THEY IMPORTANT FOR ITS RECOVERY

• Tipo: Artigo em Revista Científica Internacional
• Data: 1994

Autores

DUARTE, JA (Autor) FADEUP; CARVALHO, F (Autor) FFUP; BASTOS, ML (Autor) FFUP; SOARES, JMC (Autor) Outra; APPELL, HJ (Autor) Outra

Revista

Título: European Journal of Applied Physiology and Occupational Physiology

Vol. 68

Páginas: 48-53

ISSN: 0301-5548

Editora: Springer

Indexação

ISI Web of Knowledge - 40 Citações

Scopus - 44 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-KPM

DOI: 10.1007/bf00599241

Abstract (EN): Mice were subjected to one session of strenuous running exercise and their soleus muscles were examined in respect of changes in ultrastructure and to their concentration of reduced glutathione [GSH] which are indicators of oxidative stress. It was hypothesized that invading leucocytes contributed to oxidative stress and they were functionally inhibited in one experimental group by the administration of colchicine. Exercise led to an immediate decrease in [GSH] of about 60%, which slowly recovered during 96 h after exercise. With the administration of colchicine after exercise, [GSH] was higher than in the untreated exercise group 48 h after exercise, indicating an inhibition of the ability of leucocytes to produce oxidative stress. However, at 96 h after exercise, [GSH] was lower in the treated exercise group than in the untreated group. The morphological evaluation of the percentage of affected fibres showed that the invasion of leucocytes in creased muscle fibre damage. The results suggested that invading leucocytes enhanced production of reactive species of oxygen that may have participated in inducing muscle damage. However, inhibition of leucocyte invasion did not permit their scavenger action of removing cell debris, which appeared to produce even more oxidative stress in the muscle.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6