The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal)-Experimental assessment using a zebrafish embryo test

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

madureira, tv (Autor) Outra; cruzeiro, c (Autor) Outra; rocha, mj (Autor) ICBAS; rocha, e (Autor) FCUP

Revista

Título: Environmental Toxicology and Pharmacology

Vol. 32

Páginas: 212-217

ISSN: 1382-6689

Editora: Elsevier

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 13 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências da terra e ciências do ambiente

Outras Informações

ID Authenticus: P-002-N2S

DOI: 10.1016/j.etap.2011.05.005

Abstract (EN): Fish embryos are a particularly vulnerable stage of development, so they represent optimal targets for screening toxicological effects of waterborne xenobiotics. Herein, the toxicity potential of two mixtures of pharmaceuticals was evaluated using a zebrafish embryo test. One of the mixtures corresponds to an environmentally realistic scenario and both have carbamazepine, fenofibric acid, propranolol, trimethoprim and sulfamethoxazole. The results evidenced morphological alterations, such as spinal deformities and yolk-sac oedemas. Moreover, heart rates decreased after both mixture exposures, e.g., at 48 hpf, highest mixture versus blank control (47.8 +/- 4.9 and 55.8 +/- 3.7 beats/30 s, respectively). The tail lengths also diminished significantly from 3208 +/- 145 mu m in blank control to 3130 +/- 126 mu m in highest mixture. The toxicological effects were concentration dependent. Mortality, hatching rate and the number of spontaneous movements were not affected. However, the low levels of pharmaceuticals did interfere with the normal development of zebrafish, which indicates risks for wild organisms.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6