Dissolution characteristics of divisible tablets

• Tipo: Artigo em Revista Científica Internacional
• Data: 2000

Autores

costa, p (Autor) FFUP; amaral, h (Autor) Outra; lobo, jms (Autor) Outra

Revista

Título: S.T.P. Pharma Sciences

Vol. 10

Páginas: 373-377

ISSN: 1157-1489

Editora: Editions de Sante

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-000-Z6F

Abstract (EN): The objective of this work was to study the in vitro dissolution equivalence and divisibility of three brands of captopril tablets, applying the tablet divisibility assay described in the Portuguese Pharmacopoeia VI (FP VI). At the same time, the physical characteristics (hardness, friability) and release characteristics of whole tablets and halves and quarters resulting from the division of tablets, were analysed The dissolution test was carried out using a USP paddle apparatus. Captopril tablets (25 mg) with crossed scoring were tested. In this way, captopril doses of 25 mg (one tablet), 12.5 mg (one half tablet) and 6.25 mg (one quarter tablet) can be administered. The results obtained with tablet halves, and particularly tablet quarters, exhibited broad variations in weight which could give rise to significant differences in plasma levels.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5