Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

de Castro, B (Autor) FCUP; Gameiro, P (Autor) FCUP; Guimaraes, C (Autor) Outra; Lima, JLFC (Autor) FFUP; Reis, S (Autor) FFUP

Revista

Título: Journal of Pharmaceutical and Biomedical Analysis

Vol. 18

Páginas: 573-577

ISSN: 0731-7085

Editora: Elsevier

Indexação

ISI Web of Knowledge - 21 Citações

Scopus - 23 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-001-6NN

DOI: 10.1016/s0731-7085(98)00211-8

Abstract (EN): The effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimetric intensities and on the solubility of two beta-blockers (atenolol and nadolol) were studied at 25.0 +/- 0.1 degrees C and I = 0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the beta-blockers.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5