Study of organic compounds-water interactions by partition in aqueous two-phase systems

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Pedro P Madeira (Autor) Outra; Ana Bessa (Autor) Outra; Miguel A Teixeira (Autor) FEUP; Luis Alvares Ribeiro (Autor) FCUP; Raquel Aires Barros, MR (Autor) Outra; Alirio E Rodrigues (Autor) FEUP; Boris Y Zaslavsky (Autor) Outra

Revista

Título: Journal of Chromatography A

Vol. 1322

Páginas: 97-104

ISSN: 0021-9673

Editora: Elsevier

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 16 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-006-J3K

DOI: 10.1016/j.chroma.2013.10.085

Abstract (EN): Partition coefficients of fourteen organic compounds were determined in 10 or 20 different polymer/polymer aqueous two-phase systems (ATPS) all at physiological pH (0.15 M NaCl in 0.01 M phosphate buffer, pH 7.4). Solute-specific coefficients characterizing different types of solute-water interactions for the compounds examined were determined by the multiple linear regression analysis. It is shown that (i) the partition behavior for the polar organic compounds is affected not only by dipole-dipole and hydrogen-bond interactions with aqueous environment but, notably, in most cases also by dipole-ion interactions; (ii) it is possible to predict partition behavior for compounds with pre-determined solutespecific coefficients in ATPS with characterized solvent features; and (iii) linear combinations of the solute-specific coefficients for the organic compounds might be useful in the development of quantitative structure-activity relationship (QSAR) analysis to describe their odor detection threshold.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8