Induction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Fernando Schmitt (Autor) FMUP

Revista

Título: Experimental and Toxicologic Pathology

Vol. 59

Páginas: 425-430

ISSN: 0940-2993

Editora: Urban und Fischer Verlag Jena

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 11 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Anatomia patológica

Outras Informações

ID Authenticus: P-004-0E6

DOI: 10.1016/j.etp.2007.10.010

Abstract (EN): Aim: Acrolein (ACR) is a urinary metabolite of cyclophosphamide (CPS) and ifosfamide (IFS), which has been demonstrated to be the causative agent of hemorrhagic cystitis (HQ, induced by these compounds. In this study, we investigate the participation of cyclooxygenase-2 (COX-2) on ACR-induced HC. Methods: Male Wistar rats (150-200 g; six rats per group) were treated with distilled water or intravesical ACR and analyzed by changes in bladder wet weight, macroscopic and microscopic parameters and COX-2 expression. Results: COX-2 immunohistochemical expression was significant 12h after ACR administration mainly in subepithelial cells. ACR injection also alters some macroscopic and microscopic parameters in bladder of rats analyzed by Gray's criteria. Conclusions: COX-2 participates in the pathogenesis of ACR-induced HC first seen 12 h after initial contact between ACR and urothelium.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6