ACTIVATION OF THE C-FOS PROTOONCOGENE IN THE SPINAL-CORD FOLLOWING NOXIOUS-STIMULATION OF THE URINARY-BLADDER

• Tipo: Artigo em Revista Científica Internacional
• Data: 1994

Autores

Francisco Cruz (Autor) FMUP; António Avelino Silva (Autor) FMUP; Deolinda Lima (Autor) FMUP; COIMBRA, A (Autor) Outra

Revista

Título: Somatosensory and Motor Research

Vol. 11

Páginas: 319-325

ISSN: 0899-0220

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 41 Citações

Scopus - 40 Citações

Outras Informações

ID Authenticus: P-001-M4J

DOI: 10.3109/08990229409028876

Abstract (EN): Activation of the c-fos proto-oncogene following mechanical or chemical noxious stimulation of the urinary bladder was studied at T-12-L(2) and L(5)-S-1, the spinal cord segments of projection of the hypogastric nerve (HGN) and pelvic nerve (PN) fibers, respectively. In intact adult rats, c-fos expression was found at T-12-L(2) only in lamina I. At L(5)-S-1, Fos cells occurred in lamina I, the intermediolateral gray matter (ILG), and the dorsal commissure (DCM). These two areas contained the highest number of immunoreactive cells. Although more Fos cells were induced by mechanical than by chemical stimulation, the distribution of the reactive neurons was similar after both types of stimuli. In adult rats that had been treated neonatally with capsaicin, there was a marked fall in c-fos activation by mechanical or chemical noxious stimuli in all immunoreactive areas. The loss of Fos cells was more pronounced in ILG and DCM at L(5)-S-1 (95%) than in lamina I at the two spinal domains (70%). The confinement of c-fos activation to lamina I at T-12-L(2), the spinal cord domain of the HGN, suggests that the input carried from the bladder by this nerve is preferentially used for pain perception. The same function is expected for noxious input reaching lamina I at L(5)-S-1, the spinal cord territory of termination of the PN. However, the striking number of Fos cells in ILG and DCM supports the important role played by this nerve in the control of the micturition reflex. The marked block of c-fos activation in ILG and DCM by capsaicin suggests, in addition, that these bladder reflexogenic areas receive massive sensory input through unmyelinated C fibers.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7