Antibacterial effects of novel quaternary ammonium and phosphonium salts against Staphylococcus aureus

• Tipo: Artigo em Revista Científica Internacional
• Data: 2025

Autores

Nunes, B (Autor) Outra; Cagide, F (Autor) Outra; Anabela Borges (Autor) FEUP; Borges, F (Autor) Outra; Simoes, M (Autor) Outra

Revista

Título: JOURNAL OF APPLIED MICROBIOLOGY

Vol. 136

ISSN: 1364-5072

Indexação

ISI Web of Knowledge - 0 Citações

ISI Web of Science - Citações

Scopus - 0 Citações

Classificação Científica

CORDIS: Ciências Naturais > Ciências biológicas

FOS: Ciências médicas e da saúde > Ciências da saúde

Projetos Associados

LEPABE - Financiamento Plurianual 2020-2023 da Unidade de I&D LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

LEPABE - Projeto Estratégico do LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

InnovAntiBiofilm - Boosting Sustainable Innovation in Developing New Antibiotic Adjuvants to Control Biofilm Resistance

Outras Informações

ID Authenticus: P-018-V2Y

DOI: 10.1093/jambio/lxaf122

Abstract (EN): Aim This study investigates the mechanisms of action of a promising series of previously synthesized quaternary ammonium (QASs) and phosphonium (QPSs) salts, which have shown potent activity against Staphylococcus aureus, including methicillin-resistant strains (MRSA).Methods and results The effects of QASs and QPSs on S. aureus surface charge, total surface hydrophobicity, intracellular potassium release, membrane integrity, and ultrastructure were examined. QASs and QPSs significantly altered bacterial surface properties by reducing negative surface charge, disrupting membrane integrity, and inducing potassium leakage and propidium iodide uptake. Furthermore, S. aureus became less hydrophilic due to changes in surface hydrophobicity. Transmission electron microscopy revealed cytoplasmic leakage and the presence of electron-dense extracellular material around damaged bacterial cells upon exposure to high concentrations of these salts.Conclusions The antimicrobial activity of QASs and QPSs is driven by their ability to alter bacterial surface properties, destabilizing and disrupting membranes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11