The Power of Movement: How Exercise Influences Chemotherapy-Induced Peripheral Neuropathy

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2025

Autores

Loureiro, J (Autor) Outra; Costa-Pereira, JT (Autor) FCNAUP; Daniel Pozza (Autor) FMUP; Isaura Tavares (Autor) FMUP

Revista

Título: Biomedicines

Vol. 13

Página Final: 1103

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-018-RD9

DOI: 10.3390/biomedicines13051103

Abstract (EN): As the number of cancer patients and survivors increases, we face a rising challenge: the long-term impact of the adverse effects of cancer treatment. One of the known adverse effects is chemotherapy-induced peripheral neuropathy (CIPN), which courses with pain complaints. The treatments of CIPN have reduced efficacy. The neurobiological causes of CIPN have been mainly ascribed to peripheral nerve damage, but recent studies show effects in the brain, namely in the descending pain modulatory systems. Physical exercise seems to be associated with better outcomes in CIPN patients, but the mechanisms underlying the effects have not been discussed, namely considering the recent results of the effects of CIPN in brain structures involved in pain modulation. In this critical review, we propose that the beneficial effects of exercise in CIPN also have central mechanisms, namely neuroinflammation and oxidative stress, as well as changes in the actions of neurotransmitters and neurotrophic factors, with a direct effect on optimizing the endogenous pain modulation, namely opioids, monoamines, and endocannabinoids. The effects are multifactorial, as mood improvement and the other psychological benefits of exercise should be considered. The emerging role of the microbiome, which is affected during CIPN, also needs to be considered. This review critically synthesizes the available literature to highlight how the neurobiological effects of physical exercise make it a promising strategy for managing CIPN, both from preventive and treatment perspectives.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 22