Fibroblasts in pancreatic cancer: molecular and clinical perspectives

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2023

Autores

Rebelo, R (Autor) Outra; Xavier, CPR (Autor) Outra; Giovannetti, E (Autor) Outra; Helena Vasconcelos, MH (Autor) FFUP

Revista

Título: Trends in Molecular Medicine

Vol. 29

Páginas: 439-453

ISSN: 1471-4914

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus

Outras Informações

ID Authenticus: P-00Y-9T7

DOI: 10.1016/j.molmed.2023.03.002

Abstract (EN): Pancreatic stellate cells (PSCs) and cancer-associated fibroblasts (CAFs) are highly abundant cells in the pancreatic tumor microenvironment (TME) that mod-ulate desmoplasia. The formation of a dense stroma leads to immunosuppression and therapy resistance that are major causes of treatment failure in pancreatic ductal adenocarcinoma (PDAC). Recent evidence suggests that several sub-populations of CAFs in the TME can interconvert, explaining the dual roles (antitumorigenic and protumorigenic) of CAFs in PDAC and the contradictory results of CAF-targeted therapies in clinical trials. This highlights the need to clarify CAF heterogeneity and their interactions with PDAC cells. This review fo-cuses on the communication between activated PSCs/CAFs and PDAC cells, as well as on the mechanisms underlying this crosstalk. CAF-focused therapies and emerging biomarkers are also outlined.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15