Association of metabolic syndrome components and NAFLD with quality of life: Insights from a cross-sectional study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2024

Autores

Borges-Canha, M (Autor) FMUP; Leite, AR (Autor) Outra; Godinho, T (Autor) Outra; Liberal, R (Autor) Outra; Correia-Chaves, J (Autor) Outra; Lourenço, IM (Autor) Outra; von Hafe, M (Autor) Outra; Vale, C (Autor) Outra; Fragao-Marques, M (Autor) Outra; Pimentel-Nunes, P (Autor) Outra; Leite-Moreira, A (Autor) Outra; Carvalho, D (Autor) Outra; Freitas, P (Autor) FMUP; Neves, JS (Autor) Outra

Revista

Título: Primary Care Diabetes

Vol. 18

Páginas: 196-201

ISSN: 1751-9918

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus

Outras Informações

ID Authenticus: P-00Z-V62

DOI: 10.1016/j.pcd.2024.01.004

Abstract (EN): Aim: Metabolic syndrome (MetS) is associated with higher cardiovascular and metabolic risks, as well as with psychosocial disorders. Data regarding quality of life (QoL) in patients with MetS, point towards a significative association between MetS and a worse QoL. It remains unclear whether MetS components and non-alcoholic fatty liver disease (NAFLD) are associated with QoL in these individuals. We aimed to evaluate the association between QoL of patients with MetS and prespecified metabolic parameters (anthropometric, lipidic and glucose profiles), the risk of hepatic steatosis and fibrosis, and hepatic elastography parameters. Methods: Cross-sectional study including patients from microDHNA cohort. This cohort includes patients diagnosed with MetS, 18 to 75 years old, followed in our tertiary center. The evaluation included anamnesis, physical examination, a QoL questionnaire (Short-Form Health Survey, SF-36), blood sampling and hepatic elastography. We used ordered logistic regression models adjusted to sex, age and body mass index to evaluate the associations between the QoL domains evaluated by SF-36 and the prespecified parameters. Results: We included a total of 65 participants with MetS, with 54% being female and the mean age 61.9 +/- 9.6 years old. A worse metabolic profile, specifically higher waist circumference, lower HDL, higher triglycerides, and more severe hepatic steatosis, were associated with worse QoL scores in several domains. We found no significant association of hepatic fibrosis with QoL. Conclusion: Our data suggests that there is a link between a worse metabolic profile (specifically poorer lipidic profile and presence of hepatic steatosis) and a worse QoL in patients with MetS.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6