Novel pyridine-2,4,6-tricarbohydrazide derivatives: Design, synthesis, characterization and in vitro biological evaluation as alpha- and beta-glucosidase inhibitors

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Riaz, S (Autor) Outra; Khan, IU (Autor) Outra; Yar, M (Autor) Outra; Ashraf, M (Autor) Outra; Rehman, TU (Autor) Outra; Shaukat, A (Autor) Outra; Jamal, SB (Autor) Outra; Duarte, VCM (Autor) Outra; Alves, MJ (Autor) Outra

Revista

Título: Bioorganic Chemistry

Vol. 57

Páginas: 148-154

ISSN: 0045-2068

Editora: Elsevier

Indexação

ISI Web of Knowledge - 9 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-009-Z3K

DOI: 10.1016/j.bioorg.2014.10.007

Abstract (EN): A range of novel pyridine 2,4,6-tricarbohydrazide derivatives (4a-4h) were synthesized and its biological inhibition towards alpha- and beta-glucosidases was studied. Most of the compounds demonstrate to be active against a-glucosidase, and quite inactive/completely inactive against beta-glucosidase. A number of compounds were found to be more active against alpha-glucosidase than the reference compound acarbose (IC50 38.25 +/- 0.12 mu M); being compound 4d with the p-hydroxy phenyl motive the most active (IC50 20.24 +/- 0.72 mu M). Molecular modeling studies show the interactions of compound 4d with the active site of target alpha-glucosidase kinase.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7