Biliopancreatic diversion with duodenal switch (BPD-DS) and single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) result in distinct post-prandial hormone profiles

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Pereira, SS (Autor) ICBAS; Guimaraes, M (Autor) Outra; Almeida, R (Autor) Outra; Pereira, AM (Autor) FMUP; Lobato, CB (Autor) Outra; Hartmann, B (Autor) Outra; Hilsted, L (Autor) Outra; Holst, JJ (Autor) Outra; Nora, M (Autor) Outra; Monteiro, M (Autor) ICBAS

Revista

Título: International Journal of Obesity

Vol. 43

Páginas: 2518-2527

ISSN: 0307-0565

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 14 Citações

Outras Informações

ID Authenticus: P-00Q-03Z

DOI: 10.1038/s41366-018-0282-z

Abstract (EN): Background/objective Biliopancreatic diversion with duodenal switch (BPD-DS) is the most effective bariatric intervention to treat morbid obesity and related disorders. Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is a new bariatric procedure devised with the purpose of simplifying the complexity of the BPD-DS technique while maintaining its efficacy. However, whether BPD-DS and SADI-S result in similar fasting and post-prandial hormone profiles has not yet been studied. Therefore, the purpose of this study was to assess and compare the hormone response to a standardized mixed meal in subjects operated with BPD-DS or SADI-S. Subjects/methods Subjects submitted to BPD-DS (n = 9) or SADI-S (n = 9) 1.5 years earlier on average, with no past nor current diabetes diagnosis underwent a liquid mixed-meal tolerance test (MMTT) to assess the baseline and post-prandial profile of glucose, enteropancreatic hormones and total bile acids. Results Fasting glucose, enteropancreatic hormones and total bile acids levels after BPD-DS and SADI-S were similar. After the MMTT, the response of subjects who underwent SADI-S was characterized by higher glucose (t = 30 min: p < 0.05; iAUC: 156.1 +/- 46.2 vs. 103.4 +/- 35.8 mmol/L x min, p = 0.02), GLP-1 (t = 30 min: p < 0.05; iAUC: 5388 +/- 3010 vs. 2959.0 +/- 2146 pmol/L x min, p = 0.02), glucagon (t = 30 min: p < 0.05; iAUC: 678.7 +/- 295.2 vs. 376.9 +/- 215.7 pmol/L x min, p = 0.02), insulin (t = 30 and 45 min: p < 0.05); and C-peptide levels (t = 30 and 45 min: p < 0.05), when compared to BPD-DS. Conclusions The post-prandial hormone secretion profile after SADI-S is characterized by increased GLP-1, glucagon and insulin secretion, when compared to BPD-DS, which suggests the existence of different endocrine driven mechanisms leading to weight loss and metabolic improvement after the two procedures.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10