Uveal melanoma: physiopathology and new in situ-specific therapies

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2019

Autores

Souto, EB (Autor) Outra; Zielinska, A (Autor) Outra; Luis, M (Autor) Outra; Carbone, C (Autor) Outra; Martins Gomes, C (Autor) Outra; Souto, SB (Autor) Outra; Silva, AM (Autor) Outra

Revista

Título: Cancer Chemotherapy and Pharmacology

Vol. 84

Páginas: 15-32

ISSN: 0344-5704

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 24 Citações

Classificação Científica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-00Q-MAE

DOI: 10.1007/s00280-019-03860-z

Abstract (EN): Uveal melanoma is the most common primary intraocular tumor in adults. It can arise from melanocytes in the anterior (iris) or posterior uveal tract (choroid and ciliary body). Uveal melanoma has a particular molecular pathogenesis, being characterized by specific chromosome alterations and gene mutations (e.g., GNAQ/GNA11; BAP1), which are considered promising targets for molecular therapy. Primary treatment of uveal melanoma includes radiotherapy (brachytherapy and charged-particle therapy), phototherapy (photocoagulation, transpupillary thermal therapy, and photodynamic therapy) and surgery (local resection, enucleation and exenteration). Approximately half of patients with uveal melanoma will, however, develop metastasis, especially in the liver. The treatment of metastatic uveal melanoma includes systemic chemotherapy, immunotherapy and molecular targeted therapy. Liver-directed therapies, such as resection, chemoembolization, immunoembolization, radioembolization, isolated hepatic perfusion and percutaneous hepatic perfusion, are also available to treat metastatic uveal melanoma. Several clinical trials are being developed to study new therapeutic options to treat uveal melanoma, mainly for those with identified liver metastases. The present work discusses the physiopathology and new in situ-specific therapies for the treatment of uveal melanoma.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 18